Cocaine comes from the coco plant native to the high mountain ranges of South America. Chemical synthesization of the plant creates creates a white powder known as cocaine.
Cocaine is a very addictive stimulant with roots in medicine and even household items, dating back to 100 years years ago when it was first purified from the coco plant. According to the National Institute on Drug Abuse (NIDA):
In the early 1900s, purified cocaine was the main active ingredient in many tonics and elixirs developed to treat a wide variety of illnesses and was even an ingredient in the early formulations of Coca-Cola. Before the development of synthetic local anesthetic, surgeons used cocaine to block pain. However, research has since shown that cocaine is a powerfully addictive substance that can alter brain structure and function if used repeatedly.
Today, cocaine is a Schedule II drug, meaning it has a high potential for abuse that can lead to severe psychological or physical dependence.
Over time, users developed newer, more potent ways of ingesting the drug. Cocaine is processed in order to create a crystal (“or, “rock-like”) form of the drug known as crack. Users heat the crystal and inhale the vapors into the lungs, greatly enhancing the euphoric effects of the drug.
Street names for cocaine include blow, rock, crack, coke, and snow.
Some short-term health risks of using cocaine include constricted blood vessels, nausea, irregular heartbeat, and tremors. Snorting cocaine can lead to loss of smell and damage to the septum.
Smoking the drug can lead to respiratory distress and higher risks of infections like pneumonia. Needle injections involving cocaine present greater risks of contracting HIV, hepatitis C and other bloodborne diseases.
The rush of dopamine caused by cocaine also poses long-term, negative effects on the reward circuits I the brain. This can lead to tolerance and intense withdrawal symptoms. According to NIDA:
This flood of dopamine in the brain’s reward circuit strongly reinforces drug-taking behaviors, because the reward circuit eventually adapts to the excess of dopamine caused by cocaine, and becomes less sensitive to it. As a result, people take stronger and more frequent doses in an attempt to feel the same high, and to obtain relief from withdrawal.
Street dealers often mix cocaine with other illicit substances like amphetamine or fentanyl—a powerful synthetic opioid—to increase profits and the potency of the product. In the United States, more than 40 percent of cocaine-related overdose deaths in 2016 involved fentanyl.
Cocaine by the Numbers