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What Is Fentanyl Made From? Main Ingredients, Cutting Agents, and Adulterants

Medically Reviewed by: Charley Allen

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What Is Fentanyl Made From? Main Ingredients, Cutting Agents, and Adulterants

Fentanyl is a powerful synthetic opioid.

Opioids are medications that reduce pain by targeting opioid receptors in the brain. Most of them are produced using the poppy plant, but synthetic opioids such as fentanyl are manufactured in the lab. According to the National Institute on Drug Abuse, fentanyl is 50-100 times more powerful than morphine, another powerful (natural) opioid from which heroin is derived. So what is fentanyl made from that makes it so powerful?

In the United States, the Drug Enforcement Administration classifies fentanyl as a Schedule II substance, meaning it has a high potential for abuse and physical dependence but has a recognized medical use as a prescription drug. Fentanyl is so potent that it is now competing with heroin as the most dangerous opioid on the market.

Fentanyl is also commonly abused alongside other substances. Since it is so potent and powerful, it is often used as a cheap way of cutting more expensive drugs. However, the consequences of consuming fentanyl unwittingly can be catastrophic. Additionally, combining it with other substances often affects the brain in surprising and unpredictable ways. Using fentanyl irresponsibly in this fashion can often be fatal.

What is Fentanyl Made From? : Illegally Made Fentanyl

According to the Centers for Disease Control and Prevention, overdoses due to fentanyl are on the rise. This is in part due to the increased availability of illegally-made non-pharmaceutical fentanyl. From 2012 to 2015, the number of deaths due to overdoses from synthetic opioids such as fentanyl almost tripled. Because fentanyl is so easy to produce in large quantities, and because even a pinch of it is so powerful, drug dealers are turning more and more often to selling fentanyl, which in many areas is now more accessible than heroin. Additionally, among abused substances, fentanyl is particularly easy to ship undetected. This has contributed to a large extent toward the spread of the substance.

Adding to Heroin

Due to its affordability and potency, fentanyl is commonly used by drug dealers to cut or lace other drugs, particularly opioids such as heroin. As a result, many drug addicts who are trying to buy heroin are often consuming fentanyl as well. Unfortunately, while heroin is obviously dangerous in and of itself, consuming both drugs simultaneously exposes addicts to increased risks. Because both opioids are central nervous system depressants, the chances of respiratory depression increase.

When respiratory depression occurs, breathing slows or comes to a stop entirely. Additionally, the chances of overdoses skyrocket. This is particularly true because heroin users are consuming fentanyl accidentally, and when using opiates it is important to match potency and dose to the individual user’s tolerance and sensitivity levels.

Adding to Cocaine

It is also common for fentanyl to be mixed with cocaine and pressed into pill form. These substances, which are sold on the street under many names, are often sold without any mention of the fentanyl contained within. Combining opioids with stimulants such as cocaine is known as speedballing.

These substances, which have opposite effects, are used together because they both provide powerful and euphoric “highs” and tend to nullify the other drug’s negative effects. However, the risk of overdose increases alongside the high. Stimulants such as cocaine overwork the heart and cause the body to use more oxygen.

On the other hand, fentanyl and other depressants cause users to breathe more slowly and can even slow the rhythm of the heart itself. These contradictory effects can be life threatening.

The Problem of Not Knowing

Unfortunately for many addicts, it is often unclear what they are getting when they choose to purchase an illicit drug. Fentanyl can be added to many drugs, including heroin and cocaine. Drug dealers who are trying to profit may not mention this, which adds an additional risk factor. These shady practices can occur when fentanyl is purchased on the street, but it is becoming more and more common with drugs purchased on the Internet’s “dark web” as well.

Dangers of Prescription Drug Abuse

For this reason, it is crucial to use fentanyl only under strict medical supervision. However, even when fentanyl is taken for its legitimate purpose of treating severe and chronic pain, it can cause serious health problems. Even at a reasonable and non-abusive dose, fentanyl can cause confusion, nausea, and constipation, drowsiness and sedation, problems breathing, and sometimes unconsciousness.

Physicians often find that even patients who take fentanyl responsibly develop a tolerance and dependence on the substance. At this point, a prudent physician will often work with the patient to taper off the opioid and thereby avoid the most severe withdrawal symptoms.

For addicts who purchase fentanyl illegally or who have accidentally ingested fentanyl via an adulterant found in another substance, it is often a good idea to seek substance abuse treatment. Recovery programs such as sober living homes, rehabs, and medical detox centers can provide the support and supervision necessary to become drug-free.

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David moved to California from his hometown in North Carolina after multiple failed attempts to get sober. While living in an all-male sober living, David started to excel as a leader and mentor. These skills and tools ended up being the catalyst for his recovery and ultimately the foundation he has today. David has a passion for helping young men and sharing his experience. After working in the treatment industry he noticed a serious need for ethical sober living facilities. This prior work experience brought about David’s idea and drive to open Design For Recovery. He’s ambitious to promote growth and change within each individual client that enters the house. David has a strong presence in the house and continues to be part of mentoring young men on a daily basis.


Edited by: David Beasley

David Beasley - Design for Recovery

David Beasley is a certified RADT (Registered Alcohol/Drug Technician). David, moved to California from North Carolina after many failed attempts to get sober.

Medically Reviewed by: Charley Allen

Charley earned his Masters of Clinical Psychology from Antioch University, Los Angeles, and is a California Licensed Marriage and Family Therapist (LMFT).He teaches mindfulness to both adults and children in group setting such as schools, corporate workplaces, and medical treatment facilities.

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